Exosome

Extracellular vesicles or bubbles released from cells, especially stem cells, are called exosomes and are extremely important for the body. Exosomal structures are extracellular particles responsible for genetic information and enable communication between cells.

Molecules are the basic regulators of intracellular information between both nearby and distant cells, and molecules are carried by exosomes. DNA, RNA and proteins are transferred from one cell to another thanks to the small sac-shaped structures between 30 and 150 nanometers excreted by cells.

Exosomes make cell-to-cell communication possible by transporting molecules, which are among the most important regulators of intracellular information, between nearby and distant cells. They carry information with different purposes and functions that indicate when and how to respond to the cell.

Exosomes released by young stem cells have an extremely important effect in helping to regulate and rejuvenate regenerative processes in the body. Although exosomes are not cells, they play a critical role in all cell-to-cell communication and cell rejuvenation in the body.

Aging, chronic diseases, environmental factors, and genetic disorders can disrupt the healing process by interfering with how stem cells communicate with other cells. Since exosomes play a critical role in regulating these communication processes, they have recently been used with increasing frequency as one of the new generation cellular therapies.

Exosomes stand out with their functionality in issues such as skin repair, skin rejuvenation, and reducing inflammation in the body. Although stem cell structures are responsible for the rejuvenation of old cells, there is a risk that these cells will not be able to provide all the information the body needs. In this case, it is possible to provide new pieces of information with the exosome function in order to support the body’s healing process and make the treatment much more effective.

What is Exosome?

Exosomes can be defined in the simplest form as vesicles secreted by cells. Exosome therapy is applied using vesicles obtained from mesenchymal cells and called vesicles. Exosomes are one-thousandth the size of cells. Exosomes, which strengthen the functions of the cells they affect, play a role in the repair of the relevant cell. In this context, they transmit DNA, RNA, growth factors and amino acids to the cell they will repair.

In addition to the treatment of orthopedic injuries and various degenerative diseases, exosome therapy is frequently used due to its anti-aging feature. Exosome therapy, which is becoming an increasingly popular treatment in our country, can be preferred to be combined with stem cell therapy to increase the healing effect in the body. In this context, it can be stated that exosome therapy is a treatment applied for the repair, renewal of the skin and the reduction of skin scars, in other words, anti-aging.

How is Exosome Applied?

Exosome therapy is a method that can be used in the treatment of various diseases as well as for aesthetic purposes. Since the injected mixture within the scope of exosome treatment also contains growth factors, it is possible to trigger the natural renewal process by strengthening the hair follicles and stimulating the cells in people who have hair loss problems. In this context, exosome treatment is often preferred in cases such as thinning hair and excessive hair loss.

DNA, RNA, amino acids and hundreds of growth factors are included in the exosomes used in exosome treatment. In order to obtain exosomes from stem cells, the stem cells in the culture are first grown. Then, the exosomes are purified from the liquid medium in which the stem cells grown in the culture are located. In the next step, they are freed from the stem cells and exosomes are obtained.

The products to be used in exosome treatment must be transported in a cold chain and used without waiting after being opened. Before starting the exosome treatment, a local anesthetic cream is applied to the application area and waited for it to take effect. Then the injection is performed. No pain or ache is felt due to the effect of local anesthesia.

In order for the exosome treatment to be successful, the injected exosomes must be in high concentration. The intensive mixture injected into the application area within the scope of exosome treatment includes various components such as exosome, Q enzyme, mineral, peptide, around 50 growth factors, amino acids and vitamins.

The dosage of the mixture to be injected within the scope of exosome treatment is determined according to the needs of the treatment area and the treatment plan for each patient. Exosome treatment is performed in an extremely comfortable manner. There is no interruption in the patient’s daily life. Depending on the injected dose, it is possible for fibroblast cell proliferation to increase up to 80%, elastic synthesis to increase 3 times and collagen synthesis to increase up to 6 times with the treatment.

What are the Advantages of Exosome Treatment?

The most important feature of exosome treatment is that it has the feature of triggering the production of the skin’s basic needs naturally, minimal post-inflammatory and hyperpigmentation. Accordingly, the skin is plumped and the skin brightness is increased. As the quality of the skin tissue increases, scars on the skin are reduced. As a result, pores are reduced. Due to all these benefits it provides, exosome treatment is frequently applied to eliminate fine lines and wrinkles on the skin.

The use of the exosome procedure can also be on the agenda in the treatment of wounds and non-surgical treatment of scleroderma. Exosome treatment, which can be used to reduce the signs of aging, reduce the appearance of acne scars and repair damaged hair follicles, increases collagen production in the area where it is injected and tissue repair is provided.

Another feature of exosome treatment is that it does not have any side effects since it is based on stem cell treatment. Since none of the components injected into the body within the scope of exosome treatment are foreign, allergic side effects are not encountered.

When is the Exosome Effect Seen?

In order for the effect of exosome treatment to be seen, it is necessary to wait for the cells to complete their self-renewal process. The time period in which this process will be completed and when the results of exosome treatment will be seen may vary depending on factors such as the patient’s age, the degree of the problem to be treated and the patient’s current health status. The most important reason for this is that the body begins to respond more slowly to stem cell signals due to various factors as we age.

A certain amount of time is needed for the body to repair itself. Therefore, a period of approximately 3 to 4 months should be added for the results of exosome treatment to appear. The most effective results after exosome treatment begin to be seen in most patients within 6 to 8 months.

Who is Exosome Suitable For?

Exosome treatment can be performed for many different purposes. In this context;

-Exosome treatment can be applied to people who want to have younger skin,
-Protect their skin against the effects of aging,
-Remove skin spots,
-Correct dryness and dullness on their skin,
-Remove sunspots on their skin,
-Heal cut, surgery or acne scars on their skin.

Today, exosome treatment is used as an auxiliary method for the treatment of many different diseases. Exosome treatment, which is a frequently preferred procedure, can be applied to people who need to rejuvenate their skin against the effects of aging for aesthetic purposes and repair their skin as a result of tissue damage.